Everybody knows the old adage about how to eat an elephant.   ICPDDs and their nuances certainly qualify, and the goal here is to present information in easily digestible bits.  This is the first bite.

While the reason/reasons (“etiology” it doctor-speak) a person develops IIH/PTC/etc. remain unknown and controversial, the physiology of how the pressure develops is actually quite straightforward:  ICPDDs reflect an increase in the pressure of fluid in and around the brain.  Thus, they are a result of a disruption in the dynamics of the fluids in and around the brain.  While CSF is most commonly discussed and treated, there is another fluid that actually rules everything, including CSF:



Blood is the 800 lb Gorilla of the brain.  It is pumped into the brain primarily through the

Coronal view of Brain and Carotid arteries
The Carotid Arteries and their branches supply enormous volumes of blood to a nutrient-hungry brain. Note how close the brain is to the heart, which is just out of the bottom of the frame. Image courtesy of The Mayfield Brain Foundation.

carotid arteries at a rate of 750 to 1000 cc/minute when we are at rest; it courses through an estimated 100,000 miles of blood vessels delivering nutrients and oxygen to brain tissue.  Depleted blood is drained via the venous sinuses, a network of veins around the brain, and eventually through the jugular veins back to the heart.

Blood enters the brain at an average pressure (“Mean Arterial Pressure”, or MAP) of 90mm Hg.  It drains from the veins at a pressure of 15-20 mm Hg. Because the same amount of blood that flows into the brain has to flow out, and because venous pressure is lower than arterial pressure, the blood flow in veins must be higher to compensate (fluid dynamics, Bernoulli, a couple other Italian guys in there).  Suffice it to say that veins have to be able to carry away ALL blood that is pumped into the brain.  In addition to that important necessity, there are TWO factors of blood that must be considered in ICPDD: pressure (as expressed by MAP), and flow.  For the sake

venous sinuses
A very basic illustration of the venous sinuses responsible for carrying blood away from the brain and back to the heart.

of simplicity we will use heart rate as an indicator of blood flow.











CSF is a plasma like fluid that is made from blood in an interconnected network of small hollow areas in the brain known as ventricles.   It is produced at a very low

Ventricles of the brain
Blue areas represent CSF filled spaces. The approximate volume of the ventricles is 30 cc; total CSF in and around the brain is ~150cc. Image courtesy of the Mayfield Brain Foundation

rate of ~0.35 cc/minute from arterial blood.  Its rate of production is dependent on the am

ount of blood flowing into the brain.  CSF circulates through the ventricles and around the brain; this circulation is slow, with pulsations from blood vessels and body movement being the primary motivators.  It is primarily absorbed back into the blood circulation in the venous sinuses.

CSF is something of a Mystery Fluid.  Aside from cushioning and supporting the brain, it is thought to play a role in delivering nutrients and cleansing dead cells from the outer surface of the brain.  Deficiencies in CSF are associated with accumulations of these dead cells, known as plaques, which are themselves associated with dementias such as Alzheimers and Lewy Body.  Anyone with an ICPDD can tell you that “overdrainage”, ie, not enough ICP and/or CSF makes them feel weak and lethargic.   Again, suffice it to say that CSF is Very Important; otherwise, it would not be in our heads.


The dynamics of blood and CSF lay the groundwork for understanding ICPDDs.  ICP is a result of the interaction of these fluids inside the watertight, airtight, non-expandable skull.  These facts lead to what I call the Two Fluid Postulate:

“There are only two fluids inside the skull: blood and cerebrospinal fluid (CSF). Both are present in approximately equal volumes, 150cc. Only one flows in and out of the brain:  blood.  CSF is made from blood that enters the brain and absorbed back into the veins that drain blood away from the brain.  Intracranial pressure is the sum of the forces exerted within the skull by these two fluids.  Changes in the balance of CSF production/absorption and/or blood flow into and out of the brain will necessarily affect ICP.  Most critically, because the brain is encased in a rigid, non-expanding skull, ANY INCREASE IN ICP TRANSLATES INTO INCREASED PRESSURE DIRECTLY ON THE BRAIN.”

This is just a restatement of what is known as the Monro-Kellie Hypothesis from the 1890s by two Scottish physicians to explain what goes on inside the skull.


CSF, while the most often discussed fluid in ICPDDs, is not the only fluid in the brain.  Blood, in fact, rules everything inside the skull, including CSF.  Because the volume inside the skull is fixed, and because there practically zero extra space in the skull, any net accumulation of CSF OR Blood will cause increased ICPs, and those increased ICPs exert direct pressure on the brain itself.

In Part 2, we will look at how the dynamics of blood and CSF become disrupted. 








  1. Good morning, I read your article and found it to be very interesting. I was diagnosed in Feb 2018 with IIH because of Papliodema and LPs 5/26/17- 27.7 cm, 14.5 ml of clear csf removed 3/13/17-44.0 cm, 5 ml clear csf removed.   I was also anemic and decided to adress anemia by having hysteroscopy and consuming prescription iron over many months. I am no Ionger anemic & have been free of Papliodema and have only had 2- episodes of migraines over last year when I have over exerted and become dehydrated. I may be understanding your article on an elementary way but is it possible that I may be in “remission” or stable because blood loss has been addressed? Thank you kindly,Lisa Sanes 

    Sent from Yahoo Mail on Android


    1. Lisa: yes, anemia is definitely a factor in intracranial pressures. Inadequate blood volume and/or red blood cells can starve the brain of oxygen, causing the brain to demand higher blood flow. Higher blood flows into the brain increase the amount of blood as well as the pressure of that blood. That increased pressure leads to some swelling of brain tissue, which in turn pressurizes the CSF in and around the brain. This is the same process involved in altitude sickness and its extreme form, HACE (High Altitude Cerebral Edema). In a related fashion, dehydration and anemia cause elevated CO2 levels on the blood, and CO2 is known to strongly increase blood flow into the brain, while oxygen strongly decreases it. To directly answer your question, yes, it makes perfect sense that your “remission” is stable for the reasons you mention. and I offer prayers that it may always be so.


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